Southern Metro Divisional Response Unit have charged two men in possession of firearms and drugs.
Officers observed a Toyota utility travelling along Prices Highway just after midnight Tuesday 7 March.
The ute was intercepted shortly after in Gardiner Avenue and the vehicle was searched by police.
During the search, police allegedly located three firearms, a taser device, methylamphetamine, heroin, cash and bank cards.
Two men, both from Dandenong North, were arrested at the scene.
The driver, a 40-year-old man, was charged with multiple offences including possession of a general category handgun, possession of an unregistered longarm, possession of heroine and possession of methylamphetamine, among others.
He was bailed to appear before the Dandenong Magistrates’ Court on 25 May.
A 31-year-old man was issued with a drug diversion for the offence of possess methylamphetamine.